تهیه و بررسی اثرات ضد باکتریایی و ضد قارچی مشتقات جدید ایزاتین و ایندول واجد استخلاف هیدانتوئین

Background and Objective: Bacterial infections are an important and growing problem across the world. During the last few decades, the inappropriate consumption of antibiotics has led to increased antimicrobial resistance. A survey of literature demonstrates that isatin and indole rings are among the most favorable compounds with a potential for antimicrobial activity. Therefore in this study some novel isatin and indole derivatives coupled with hydantoin moiety were synthesized using a hybridization approach in order to evaluate the relationship between structure and antibacterial/antifungal activity. Materials and Methods: The derivatives were prepared in good yields and their structures were confirmed using H-NMR, IR, and Mass Spectrometry. The antibacterial/antifungal activity of compounds was evaluated using the Broth Microdilution method on a series of gram positive and gram negative bacterial strains and Aspergillus niger. Results: Among the tested compounds, the indole derivative #5 exhibited the highest activity against Pseudomonas aeruginosa with a MIC value of 31.25 µg/mL. Conclusion[vog1] : These synthesized derivatives showed effective antibacterial activity mainly against Pseudomonas aeruginosa. On the other hand the tested compounds had appropriate spectrum effect ,because they showed antibacterial effect on both positive and negative strains.  [vog1] the English conclusion s the hould be written as Persian conclusion.